“Iron deficiency is a medical condition that leads to anemia.” Deepa Sekhar, M.D., MSc. Penn State Health Pediatrics


11 Million Americans or more have the genes that can result in too much iron.


Iron deficiency with and without anemia are a key focus areas for Iron Disorders Institute.

Understanding Iron Deficiency Anemia

:What is iron deficiency? 
Iron deficiency is a condition resulting from too little iron in the body. Iron deficiency is the most common nutritional deficiency and the leading cause of anemia in the world. In the USA, despite food fortification, iron deficiency is on the rise in certain populations. Iron deficiency at critical times of growth and development can result in premature births, low birth weight babies, delayed growth and development, delayed normal infant activity and movement. Iron deficiency can result in poor memory or poor cognitive skills (mental function) and can result in poor performance in school, work, and in military or recreational activities. Lower IQs have been linked to iron deficiency occurring during critical periods of growth.

Signs and symptoms of iron deficiency
A person who is iron deficient may also be anemic and as a result may have one or more symptoms of anemia. These can include, chronic fatigue, weakness, dizziness, headaches, depression, sore tongue, sensitivity to cold (low body temp), shortness of breath doing simple tasks (climbing stairs, walking short distances, doing housework), restless legs syndrome, pica (the desire to chew ice or non-food items,) and loss of interest in work, recreation, relationships, and intimacy.

Causes iron deficiency
Iron deficiency can be the result of numerous and multiple causes. These fall into two broad categories: an increased need for iron and/or decreased intake or absorption of iron.

Increased demand:
Iron deficiency can occur during rapid periods of growth. For this reason nature makes certain that developing fetuses, newborns and infants up until the age of about six months have an ample supply of iron. Conditions that result in iron deficiency include blood loss from heavy menstruation, pregnancy, frequent or excessive blood donation, fibroids, digestive tract disease (including infections), as well as surgeries and accidents. Iron deficiency can also be caused by certain medications, some dietary supplements or substances that cause bleeding such as pain relievers with aspirin, and also as a result of poisoning from lead, toxic chemicals or alcohol abuse.

Decreased intake or absorption  
Decreased intake or absorption can occur in diets that do not include heme iron, the iron found in meat and shellfish. Heme iron is absorbed more efficiently than non-heme iron found in plants and dietary supplements. Other nutrients, however, such as vitamins C and B12, folate or zinc can facilitate sufficient non-heme iron absorption. Consuming certain foods and medications can interfere with the absorption of iron. These include dairy products, coffee, tea, chocolate, eggs, and fiber. Medication that inhibit iron absorption include antacids, proton pump inhibitors (to treat acid reflux) or calcium supplements. Disease conditions can also limit iron absorption; this can happen as a result of insufficient stomach acid, lack of intrinsic factor (IF), celiac disease, inflammatory conditions such as Crohn’s disease, and in autoimmune diseases and hormone imbalances.

Most at risk for iron deficiency
Women, children and the elderly are most at risk. African American and Hispanic women and their young children are prone to iron deficiency, possibly because of diet or perhaps different hemoglobin needs. Men are rarely iron deficient; but when they are, it is generally due to blood loss from the digestive tract (sometimes indicating disease), diseases that affect iron absorption, and in some cases, alcohol abuse. Except for those who are strict vegetarians, men rarely have dietary iron deficiency.

How iron deficiency is detected and diagnosed
The tests used most often to detect iron deficiency include hemoglobin (the iron-containing protein in the blood), serum ferritin, which indicates the amount of iron stored in the body, and serum iron and iron-binding capacity (IBC, UIBC or TIBC).

The latter measures are used to calculate transferrin-iron saturation percentage (TS%), a measure of iron in transit in the serum. Serum ferritin is a very important test because it helps distinguish between iron deficiency anemia and anemia of chronic disease (also called anemia of inflammatory response). In cases of iron deficiency anemia, iron supplements can be helpful; but in cases of anemia of chronic disease, iron supplements could be harmful.


Other tests might include: a complete blood count, zinc protoporphyrin, free erythrocyte protoporphyrin or reticulocyte hemoglobin content (CHr).  To learn more about these tests visit tests to determine iron levels.

A diagnosis of iron deficiency can be made when a person has both low hemoglobin and hematocrit and low serum ferritin. Serum iron and transferrin-iron saturation percentage will also be low in a person who is iron deficient. Iron deficiency without anemia can occur when a person has a normal hemoglobin, but below normal serum ferritin and/or transferrin saturation. Iron deficiency with anemia can occur when a person has low values of both serum ferritin and hemoglobin.

How iron deficiency is treated
The approaches used to treat iron deficiency depend on the presence or threat of anemia and its causes, which may be increased demand for iron (pregnancy, growth spurt), blood loss (heavy periods, giving birth, surgery, injury, disease), diet or behavior, interference with iron absorption, and abnormal blood cell formation or management. Some approaches are as simple as dietary changes and others involve taking iron supplements, which are available in heme and non heme form. Some people with significant iron deficiency might require iron infusions or whole blood transfusions to restore iron sufficiency.

If you suspect that you are iron deficient, we encourage you to work with a medical professional to find out why you are iron deficient and then to increase your knowledge about the different ways low iron stores can be replenished. Visit our Iron Tools, and read the Anemia Starter Kit. Then, you can evaluate the best approaches to replenish iron levels.

Links to more information about iron deficiency:

US Centers for Disease Control and Prevention MMWR (CDC Morbidity and Mortality Weekly Report


US Centers for Disease Control and Prevention Division of Nutrition

The Agency for Healthcare and Research Quality (AHRQ)




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